<html><!-- InstanceBegin template="/Templates/subpage_scitech_projects.dwt" codeOutsideHTMLIsLocked="false" --> <head> <!-- InstanceBeginEditable name="doctitle" --> <title>Collaborative Imaging Biomarker Center - a Flagship R&D Project for Economic Development</title> <!-- InstanceEndEditable --> <% session("pageTitle")="initiatives" %> <!-- InstanceBeginEditable name="subpage" --> <% session("subPageTitle")="projects" %> <!-- InstanceEndEditable --> <!--#include file="common.asp" --> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> <link rel="stylesheet" href="micorp.css" type="text/css"> <script language="JavaScript"> <!-- function mmLoadMenus() { if (window.mm_menu_pub_0) return; window.mm_menu_init_0 = new Menu("root",245,17,"Arial, Helvetica, sans-serif",12,"#FFFFFF","#003366","#003366","#FFFFFF","left","middle",3,0,50,-5,7,true,true,true,0,false,true); mm_menu_init_0.addMenuItem("Financial Services Leadership Group", "location='init_fslg.asp'"); mm_menu_init_0.addMenuItem("US-China Leadership Development", "location='init_USChina.asp'"); mm_menu_init_0.addMenuItem("Innovation&nbsp;Partnerships", "location='gm2015_innovation.asp'"); mm_menu_init_0.addMenuItem("Recovery&nbsp;Act", "location='recovery.asp'"); mm_menu_init_0.addMenuItem("IT Security R+D Center", "location='init_itsecurity.asp'"); mm_menu_init_0.addMenuItem("Consumer&nbsp;Confidence", "location='init_consumerconf.asp'"); mm_menu_init_0.hideOnMouseOut=true; mm_menu_init_0.menuBorder=1; mm_menu_init_0.menuBorderBgColor='#777777'; window.mm_menu_pub_0 = new Menu("root",179,17,"Arial, Helvetica, sans-serif",12,"#FFFFFF","#003366","#003366","#FFFFFF","left","middle",3,0,50,-5,7,true,true,true,0,false,true); mm_menu_pub_0.addMenuItem("Index&nbsp;by&nbsp;Topic","location='pub.asp'"); mm_menu_pub_0.addMenuItem("Consumer&nbsp;Confidence&nbsp;Reports","location='pub.asp#consumerconf'"); mm_menu_pub_0.addMenuItem("Progress&nbsp;Reports","location='pub.asp#progressreports'"); mm_menu_pub_0.addMenuItem("Public&nbsp;Opinion&nbsp;Surveys","location='pub.asp#pubopinion'"); mm_menu_pub_0.hideOnMouseOut=true; mm_menu_pub_0.bgColor='#555555'; mm_menu_pub_0.menuBorder=1; mm_menu_pub_0.menuBorderBgColor='#777777'; mm_menu_pub_0.writeMenus(); } // mmLoadMenus() function MM_preloadImages() { //v3.0 var d=document; if(d.images){ if(!d.MM_p) d.MM_p=new Array(); var i,j=d.MM_p.length,a=MM_preloadImages.arguments; for(i=0; i<a.length; i++) if (a[i].indexOf("#")!=0){ d.MM_p[j]=new Image; d.MM_p[j++].src=a[i];}} } function MM_swapImgRestore() { //v3.0 var i,x,a=document.MM_sr; for(i=0;a&&i<a.length&&(x=a[i])&&x.oSrc;i++) x.src=x.oSrc; } function MM_findObj(n, d) { //v4.01 var p,i,x; if(!d) d=document; if((p=n.indexOf("?"))>0&&parent.frames.length) { d=parent.frames[n.substring(p+1)].document; n=n.substring(0,p);} if(!(x=d[n])&&d.all) x=d.all[n]; for (i=0;!x&&i<d.forms.length;i++) x=d.forms[i][n]; for(i=0;!x&&d.layers&&i<d.layers.length;i++) x=MM_findObj(n,d.layers[i].document); if(!x && d.getElementById) x=d.getElementById(n); return x; } function MM_swapImage() { //v3.0 var i,j=0,x,a=MM_swapImage.arguments; document.MM_sr=new Array; for(i=0;i<(a.length-2);i+=3) if ((x=MM_findObj(a[i]))!=null){document.MM_sr[j++]=x; if(!x.oSrc) x.oSrc=x.src; x.src=a[i+2];} } //--> </script> <script language="JavaScript" src="mm_menu.js"></script> <!-- InstanceBeginEditable name="head" --><!-- InstanceEndEditable --><!-- InstanceParam name="optionalBreadcrumb" type="boolean" value="true" --> <!-- InstanceParam name="OptionalRegion1" type="boolean" value="true" --> <!-- InstanceParam name="relatedinformation" type="boolean" value="true" --> <!-- InstanceParam name="OptionalBreadcrumb2" type="boolean" value="true" --> <!-- InstanceParam name="leftbar3" type="boolean" value="true" --> </head> <body bgcolor="#FFFFFF" text="#000000" leftmargin="0" topmargin="0" onLoad="MM_preloadImages('pics/initiaves_on.gif','pics/services_on.gif','pics/events_on.gif','pics/clients_on.gif')"> <a name="top"></a> <script language="JavaScript1.2">mmLoadMenus();</script> <table width="750" border="0" cellspacing="0" cellpadding="0" height="100%"> <!--DWLayoutTable--> <tr> <td width="750" height="75"> <table width="750" border="0" cellspacing="0" cellpadding="0"> <tr height="75"> <td width="232" height="75" rowspan="2" valign="middle" ><a href="index.asp"><img src="pics/mi_corp_logo.jpg" width="232" height="47" border="0"></a></td> <td width="518" height="35" class="toplinks" valign="bottom"> <div align="right"> </div></td> </tr> <tr height="20"> <td width="518" height="20"> <table width="516" height="20" border="0" cellspacing="0" cellpadding="0"> <!--DWLayoutTable--> <tr> <td width="281" height="20">&nbsp;</td> <td width="97" valign="top" class="toplinks"><a href="about.asp" class="toplinks">ABOUT</a></td> <td width="57" valign="top" class="toplinks"><a href="press.asp" class="toplinks">NEWS</a></td> <td width="69" valign="top" class="toplinks"><a href="contact.asp" class="toplinks">CONTACT</a></td> <td width="12">&nbsp;</td> </tr> </table></td> </tr> </table></tr> <tr> <td height="25"> <table width="750" height="25" border="0" cellspacing="0" cellpadding="0" bgcolor="791730"> <tr valign="top" height="25"> <td width="150" align="center"><a href="corpclient_intro.asp" onMouseOver="MM_swapImage('corpclient','','pics/corpclient_on.gif',1)" onMouseOut="MM_swapImgRestore()"><img src="pics/corpclient_<%=corpclient%>.gif" name="corpclient" width="150" height="25" border="0" align="center" id="corpclient"></a></td> <td width="150" align="center"><a href="init_intro.asp" onMouseOver="MM_showMenu(window.mm_menu_init_0,0,25,null,'initiatives');MM_swapImage('iniatives','','pics/initiaves_on.gif',1)" onMouseOut="MM_startTimeout();;MM_swapImgRestore()"><img src="pics/initiaves_on.gif" name="initiatives" width="150" height="25" border="0" id="initiatives"></a></td> <td width="150" align="center"><a href="service_intro.asp" onMouseOver="MM_swapImage('services','','pics/services_on.gif',1)" onMouseOut="MM_swapImgRestore()"><img src="pics/services_<%=services%>.gif" name="services" width="150" height="25" border="0" align="center" id="services"></a></td> <td width="150" align="center"> <a href="client_intro.asp" onMouseOver="MM_swapImage('clients','','pics/clients_on.gif',1)" onMouseOut="MM_swapImgRestore()"><img src="pics/clients_<%=clients%>.gif" name="clients" width="150" height="25" border="0" align="center" id="clients"></a></td> <td width="150" align="center"><a href="pub.asp" onMouseOver="MM_showMenu(window.mm_menu_pub_0,-33,25,null,'pubs');MM_swapImage('pubs','','pics/pubs_on.gif',1)" onMouseOut="MM_startTimeout();;MM_swapImgRestore()"><img src="pics/pubs_<%=publications%>.gif" name="pubs" width="150" height="25" border="0" align="center" id="pubs"></a></td> </tr> </table></td> </tr> <tr> <td height="50" valign="top"><img src="pics/<%=pageHeader%>" width="750" height="50"> </td> </tr> <tr> <td height="1596" valign="top"> <table width="100%" cellspacing="0" cellpadding="5"> <!--DWLayoutTable--> <tr> <td width="133" valign="top"> <table width="100%" border="1" bordercolor="#CCCCCC" cellspacing="0" cellpadding="5"> <tr> <td width="145" valign="top"> <p class="hr">&nbsp;</p> <p class="hr"><a href="init_scitech.asp" class="<%=getClass("scitech")%>">Science &amp; Technology</a></p> <p class="hr">&nbsp;</p> <hr align="center" size="1" noshade> <!-- InstanceBeginEditable name="leftbar1" --> <p class="redsubhead">CIBC Core Documents</p> <span class="11pt_text"><a href="http://www.massinsight.com/docs/CIBC%20Executive%20Summary.pdf">Executive Summary</a><br> <br> <a href="http://www.massinsight.com/docs/CIBC%20One-page%20Summary.pdf">One-page Summary</a><br> <br> <a href="http://www.massinsight.com/docs/CIBC%20Economic%20Impact.pdf">Economic Impact</a><br> <br> <a href="http://www.massinsight.com/docs/Imaging%20Biomarker%20White%20Paper.pdf">White Paper [pdf]</a></span> <!-- InstanceEndEditable --> <hr align="center" size="1" noshade> <!-- InstanceBeginEditable name="leftbar2" --> <p class="redsubhead"><a href="CIBC_resources.asp">Additional Resources</a></p> <!-- InstanceEndEditable --> <hr align="center" size="1" noshade> <p class="redsubhead"><!-- InstanceBeginEditable name="EditRegion11" --> <p class="redsubhead">In the News <p class="smalltext_bold"><img src="pics/Mass%20High%20Tech%20sm.gif" width="102" height="64"><br> <a href="http://www.massinsight.com/press/2006-01-16_Biomarker%20center%20proposed%20by%20execs_MHT.pdf">Biomarker center proposed by execs, academia to aid in pharma research<br> Mass High Tech, January 2006 </a></p> <!-- InstanceEndEditable --></p> <p class="hr">&nbsp;</p></td> </tr> </table></td> <td width="434" valign="top"> <p class="breadcrumbs"><a href="index.asp" class="breadcrumbs">Home</a> &gt; <a href="init_intro.asp" class="breadcrumbs">Initiatives</a> <!-- InstanceBeginEditable name="optionalBreadcrumbs" --> &gt; <a href="init_scitech.asp" class="breadcrumbs">Science &amp; Technology</a><!-- InstanceEndEditable --> <!-- InstanceBeginEditable name="EditRegion10" -->&gt; CIBC<!-- InstanceEndEditable --> </p> <!-- InstanceBeginEditable name="headline" --> <p class="header_blue">Collaborative Imaging Biomarker Center (CIBC)<br> <span class="12pt_text">A Flagship R&D Project for Economic Development</span></p> <!-- InstanceEndEditable --> <!-- InstanceBeginEditable name="news" --> <p align="left" class="14pttext_bold">November 20, 2006--Due Diligence Phase Underway</p> <p class="bodytext">The initial phase of the due diligence for the Collaborative Imaging Biomarker Center is now underway. A team of consultants from L.E.K. Consulting, led by John Westwood, Vice President of Life Sciences, has held an initial meeting with the CIBC Steering Committee and Mass Insight. Over the next several weeks, the core CIBC and L.E.K. team will further develop the model for the center and then validate that model with a wider group of companies and institutions within the life sciences community. The resulting business model and initial economic impact assessment will be completed by year end. </p> <!-- InstanceEndEditable --> <span class="bodytext"><!-- InstanceBeginEditable name="pageCopy" --> <hr> <p class="redsubhead">The Demand</p> <p class="bodytext">Years of increased R&D expenditure by the pharmaceutical industry and the federal government have actually coincided with a decline in new drugs approved for use. At the same time, the cost of developing drugs continues to increase substantially, $800 million per approved compound by recent estimates. A significant portion of that cost represents failed projects. Lowering the number of failed projects, and shortening the time to identify failures would significantly lower the cost of drug development. </p> <p class="redsubhead">The Goal</p> <p class="bodytext">The proposal to create a collaborative imaging biomarker center addresses the significant opportunity to accelerate the development of new therapeutics for the treatment of human disease by leveraging the collective R&D capability represented in the region s life science industry, universities, academic medical centers and hospitals. The project would advance the use of imaging biomarkers for early evidence of therapeutic efficacy before taking candidates into clinical testing as well for use as surrogate endpoints for regulatory approval. </p> <p class="redsubhead">The Role of Imaging Biomarkers</p> <p class="bodytext">Biomedical imaging is widely viewed as one of the most promising tools to improve the process of drug development and reduce the costs of failure. Advances in imaging technology along with increased understanding of molecular and cellular processes have opened the floodgates for a range of new indicators to be leveraged in pharmaceutical development. These novel indicators  imaging biomarkers  are showing the presence or progress of disease, the reach, effectiveness or toxicity of proposed drugs and the response to therapy at cellular and molecular levels of detail and precision never before possible. Industry, funding agencies and regulators alike see the deployment of these imaging biomarkers and the enabling technology as a important new way to </p> <ol> <li>improve the selection of drug candidates to take into expensive clinical trials </li> <li>shorten the trials themselves </li> <li>accelerate regulatory approval </li> </ol> <p class="redsubhead">Current project phase - Due Diligence</p> <p class="bodytext">The working group is beginning the due diligence phase of the project focused on: </p> <ol> <li><strong>opportunity validation</strong> - developing and testing the model for the center </li> <li><strong>partnership development</strong> - both current and new industry and academic partners and sponsors </li> <li><strong>economic impact analysis</strong> - for the Massachusetts life sciences cluster </li> <li><strong>business model and business plan definition</strong> to proceed to implementation </li> </ol> <p class="bodytext">The Executive Committee of the John Adams Innovation Institute has voted to support the due diligence phase of the Collaborative Imaging Biomarker Center project. Thanks go the University of Massachusetts Medical Center who submitted the CIBC proposal and our partners who provided letters of support highlighting the importance this project. <br><br> For more information on the Collaborative Imaging Biomarker Center, email <a href="mailto:mgreis@massinsight.com">mgreis@massinsight.com</a>. </p> <p class="bodytext">Back to <a href="#top">top</a> <img src="pics/up.gif" width="8" height="8"></p> <!-- InstanceEndEditable --></span></td> <td width="140" valign="top"><table width="100%" border="1" bordercolor="#CCCCCC" cellspacing="0" cellpadding="5"> <!--DWLayoutTable--> <tr> <td width="128" valign="top" class="bodytext"> <!-- InstanceBeginEditable name="EditRegion9" --> <p align="center"><span class="11pttext"><a href="#" class="redsubhead">Project Sponsors</a>:</span> <p align="center"><img src="http://www.massinsight.com/pics/Merck%20Research_logo_123x41.jpg" width="123" height="41"alt="Merck"></p> <p align="center"><img src="http://www.massinsight.com/pics/UMassMedSchool.jpg" alt="UMass Medical School" width="50" height="65"> </p> <p align="center"><img src="http://www.massinsight.com/pics/Biogen%20Idec%20logo_122x52.jpg" alt="Biogen Idec" width="122" height="52"></p> <p align="center"><img src="http://www.massinsight.com/pics/AstraZeneca_123x34.jpg" alt="AstraZeneca" width="123" height="34"></p> <p align="center"><img src="http://www.massinsight.com/pics/MTC_JohnAdamsInstitute_125x45.gif" alt="John Adams Institute" width="124" height="45"> </p> <p align="center"><img src="http://www.massinsight.com/pics/BrighamWomensHopsitalLogo_123x31.jpg" alt="Brigham and Women's Hospital" width="123" height="31"> </p> <p align="center"><img src="http://www.massinsight.com/pics/Abbott%20Labs%20logo_123x39.jpg" alt="Abbott Laboratories" width="123" height="39"> </p> <p class="11pt_text"><a href="#" class="redsubhead">Executive Advisory Committee:<br> </a> <strong>Jeff Hanke</strong>, Vice President for Cancer Research, AstraZeneca<br> <br> <strong>Richard Hargreaves</strong>, Vice President of Imaging, Merck Research Laboratories<br> <br> <strong>Peter Isakson</strong>, Divisional Vice President, Immunology Research, Abbott Bioresearch Center<br> <br> <strong>John Sullivan</strong>, Vice Chancellor for Research, University of Massachusetts Medical School<br> <br> <strong>William Terry</strong>, Executive Associate Director, The Reynolds Clinical Cardiovascular Research Center, Brigham and Women s Hospital<br> <br> <strong>Josef H. von Rickenbach</strong>, Chairman and CEO, PAREXEL International<br> <br> <strong>Ralph Weissleder</strong>, Professor of Radiology and Director of the Center for Molecular Imaging, Massachusetts General Hospital <br> <br> </p> <p>&nbsp;</p> <!-- InstanceEndEditable --> <p>&nbsp;</p></td> </tr> </table></td> </tr> </table></td> </tr> <tr> <td height="21">&nbsp;</td> </tr> </table> <script type="text/javascript"> var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); </script> <script type="text/javascript"> try { var pageTracker = _gat._getTracker("UA-8359177-1"); pageTracker._trackPageview(); } catch(err) {}</script> </body><!-- InstanceEnd --></html>